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The IEEE Engineering in Medicine and Biology Society, Chicago Chapter is honored to present Dr. Muna Aryal, a promising early-career researcher in the field of ultrasound-mediated brain drug delivery.

Delivery of therapeutics into the brain is challenging because almost 100% of large and 98% of small molecules that exist in today’s medicine are stopped by the special nature of brain vasculature, the blood-brain barrier (BBB) before entering into the brain tissue from the systemic blood circulation. Different methods have been used to overcome those challenges either by directly injecting drugs into the targeted brain tissue via stereotactic surgeries or by designing new pharmaceuticals, but they are invasive and non-targeted. Low intensity transcranial focused ultrasound-mediated brain drug delivery is a promising technology that can noninvasively deliver any-sized drugs with millimeter resolution to any point in the human brain with FDA-approved hardware. During this talk, Dr. Aryal will introduce three different ultrasound-based brain drug delivery techniques; the blood-brain barrier opening, the ultrasonic drug uncaging, and the ultrasonic glymphatic perturbation. She will then shed light on their applications for brain cancer treatment, neuromodulation, neuroimaging, and Alzheimer’s treatment.



December 14, 2021
7:00 pm - 8:00 pm CST
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