Chicago Section

Zoom: https://argonne.zoomgov.com/j/16065561430

Speaker: Professor MONTSERRAT RIVAS
Department of Physics & IUTA, University of Oviedo, SPAIN

Date: Monday, May 1, 2023
Time: 11:00 AM CDT
Location: Building 242-H202

HOST: Valentine Novosad, Materials Science Division, Argonne National Laboratoey

Abstract:

The Covid-19 pandemic has made us realize the great interest in rapid diagnostic tests [1]. At the same time, we are aware of their limitations: their low sensitivity for some applications (many fake negative results) and their binary response (positive/negative). The COVID-19 tests are lateral flow immunoassays (LFIAs) in which the antigen is labelled with a gold nanoparticle to make it visible. Our work uses a magnetic nanoparticle-based sensor [2] to build a rapid diagnostic test with improved sensitivity and quantifying capacities. Superparamagnetic iron oxide nanoparticles provide a brownish color and can be quantified by various types of sensors, allowing the development of immunochromatographic tests with quantitative capability. Additionally, they can be used for immunomagnetic separation and concentration of the molecule in a small volume, improving both selectivity and sensitivity. In this talk, the requirements of the magnetic labels and the associated sensing quantifying methods will be reviewed. Examples of their applicability and advantages in healthcare, the environment, and the food industry will be analyzed [3].

We acknowledge support from the Spanish Ministry of Science and Innovation (PLEC2022-009490), the Principality of Asturias (AYUD/2021/51822 and AYUD/2021/57470), and the Instituto Universitario de Tecnología Industrial de Asturias (IUTA / FUO-22-236).

References:
[1] C Parolo, et al, Tutorial: design and fabrication of nanoparticle-based lateral-flow immunoassays, Nat Protoc 15 (2020) 3788.
[2] JL Marqués et al, New Perspective on Planar Inductive Sensors: Radio-Frequency Refractometry for Highly Sensitive Quantification of Magnetic Nanoparticles, Sensors. 2023; 23(5):2372.
[3] A. Moyano et al, Magnetic immunochromatographic test for histamine detection in wine, Anal. Bioanal. Chem. 411 (2019), 6615; A. Moyano et al, Magnetic immunochromatographic test for histamine detection in wine, Diagnostics 10 (2020) 288; M. Salvador, et al, Magnetic Nanoclusters Increase the Sensitivity of Lateral Flow Immunoassays for Protein Detection: Application to Pneumolysin as a Biomarker for Streptococcus pneumoniae. Nanomaterials 12 (2022), 2044

Biography

Montserrat Rivas received her B.Sc. degree in Physics from the Basque Country University and her Ph.D. from the University of Oviedo (Spain), where she has been an associate professor since 2008. She has 30 years of experience in higher education, teaching applied physics for engineers and physicists. She has pioneered initiatives in bilingual teaching, e-campus, and game design to enhance education.

She is the leader of a the MAGNES research group (https://nanobioap.org/uniovi_magnes/) of 17 people doing interdisciplinary research (physicists, chemists, and engineers working closely with biologists and medical doctors) on magnetic materials for bio-applications and energy. In 2017 and 2019, respectively, she was the general chair of the first conference on Nanomaterials Applied to Life Sciences and the 10th International Conference on Fine Particle Magnetism. In 2020, she was appointed Chair of the Spanish Club of Magnetism. She has been a member and a topic leader of the program committees of several Intermag, MMM, Joint Euroopean Magnetism Symposia conferences, where she organized and chaired symposia on bioapplications of nanomagnetism. Montserrat is currently the chair of the Women in Magnetism of the IEEE Magnetics Society and the Editor-in-chief of its section in IEEE Access. In 2024 she will be the general chair of the IEEE NANO 2024.

Argonne National Laboratory
H202
Lemont, IL